Cluster Summary Statistic Table

Pairwise Test Results Table

Full Table of Clustering Results

Guide to using the App

Contacts

• Heather Marriott heather.marriott@kcl.ac.uk
• Guy Hunt guy.hunt@kcl.ac.uk
• Alfredo Iacoangeli alfredo.iacoangeli@kcl.ac.uk

Gene Expression Clustering

Gene expression and phenotypic file upload, clustering settings and figures of the clustering results.

Transcriptional Age Analysis

Transcriptional age analysis settings and figures of the results.

Phenotypic Comparison

Phenotypic comparison settings and figures of the results.

Full Results Table

A downloadable CSV of the clustering and transcriptional age results.

Affiliations, Funding and Acknowledgements

1. Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, SE5 9NU, UK
2. Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
3. GlaxoSmithKline (GSK), Brentford, Middlesex, UK
4. Perron Institute for Neurological and Translational Science, Nedlands, WA 6009, Australia
5. Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Murdoch, WA 6150, Australia
6. National Institute for Health Research Biomedical Research Centre and Dementia Unit at South London and Maudsley NHS Foundation Trust and King’s College London, London, UK

ROSALIND: We acknowledge use of the research computing facility at King’s College London, Rosalind (https://rosalind.kcl.ac.uk), which is delivered in partnership with the National Institute for Health Research (NIHR) Biomedical Research Centres at South London & Maudsley and Guy’s & St. Thomas’ NHS Foundation Trusts, and part-funded by capital equipment grants from the Maudsley Charity (award 980) and Guy’s & St. Thomas’ Charity (TR130505).

A.I is funded by the Motor Neurone Disease Association. This study represents independent research partly funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London.

The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, King’s College London, or the Department of Health and Social Care.

Human post-mortem tissue was obtained from the Medical Research Council London Neurodegenerative Diseases Brain Bank (King’s College London), a member of the Brains for Dementia Research Network and from the Target ALS Human Postmortem Tissue Core, New York Genome Center for Genomics of Neurodegenerative Disease, the Amyotrophic Lateral Sclerosis Association and the Tow Foundation.

Tutorial Video

An Example Phenotypic File

An Example Gene Expression File